For Clinicians

Recent Study Shows Children with Autism Viewed as Less Friendly by Peers

First impressions matter: whether you are looking at facial expressions, gestures, or just general appearance, people are quick to form judgments about others. Many researchers have studied nonverbal expressivity, or the human ability to express internal emotions or feelings without using verbal language. Facial expressions are a key form of nonverbal communication, especially in making a positive first impression.

flateffectA common symptom in individuals diagnosed with autism spectrum disorders (ASDs) is the inability to read facial expressions or pick up on subtle social cues, making it difficult to connect with others. Research studies examining expressivity in children with ASDs also find patterns of flat affect and bizarre facial expressivity. Flat affect refers to a lack of emotional reactivity, meaning any sort of facial animation or expressive gestures are very minimal.

While flat affect is well documented in the field of autism, a recent study conducted at the University of London examined the influence that this poor expressivity can have in terms of forming first impressions.

Published in the journal Autism, the study looked at the initial impressions that typically developing children form about other children featured in brief videos. Forty-four typically developing children watched a series of brief, silent videos. The videos featured a mix of typically developing children and children with ASDs, all of similar age. The children viewing the videos were unaware that any of the children in the videos were on the autism spectrum.

After watching, the viewers were asked to give friendship ratings of all the children in the videos. Results indicated that the children formed an impression of the video subjects with ASDs in as little as 30 seconds. Viewers rated children with ASDs lower on nearly all measures of the friendship scale in comparison to the typically developing peers. For example, viewers indicated they were less likely to want to be friends with these children, less likely to want to play with these children. Viewers also rated theses subjects as less trustworthy.

This study determined that even when exposure time is brief, impression formation is less positive towards children with ASDs. Unfortunately, the results of this study are not heartening. Children with ASDs struggle socially, and it is likely these negative first impressions are contributing this peer rejection. These findings should be considered and used to create thoughtful strategies to help remedy this problem.

Specialists should consider the importance of first impressions and focus on improving facial expressivity in individuals with ASDs at a young age. In addition, schools should make a dedicated effort to educate typically developing children about autism and associated symptoms. Educating these children and increasing awareness will hopefully encourage a more thoughtful first impression formation process.

This is one of many of The Autism Research Foundation’s goals. We provide many awareness programs in the community in hopes of improving the quality of relationships in individuals with autism. To learn more about some of these programs, click here.

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Poem: Acceptance of Autism

Acceptance of Autism 

Wanting to be free

Wanting to be me

Trying to make people see

And accept the real me

Some people think my voice is too loud

And that my mannerisms strike them as being odd

This perception of me by others keeps me feeling blue

But there are plenty of struggles in life that I must get through

I am determined to show my critics my true personality

Hoping that people move away from their narrow-minded mentalities

I want them to know that I am a bright young man

Who is willing to take on as many challenges in life as I can

— Scott Lentine, a smart, poetic, and inspiring 26-year-old man who happens to have autism

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Hopes for an Autism-Detecting Blood Test

Researchers at the JC Self Research Institute of the Greenwood Genetic Center (GGC) have reported an exciting new finding that may allow for earlier diagnosis of individuals with autism spectrum disorders (ASDs), as well as a clearer understanding of the disorder.

Their study found that individuals with ASDs showed significantly decreased metabolism of the amino acid L-tryptophan when compared to normally developing persons, as well as individuals with other neurodevelopmental disorders. Decreased metabolism suggests there is a delay in the processing of this amino acid.

L-tryptophan is an amino acid used by cells to make protein. The body cannot produce L-tryptophan, therefore it must be obtained from the diet. Common sources include chicken, tuna, and turkey. This amino acid plays a significant role in brain development and function. L-tryptophan serves as a critical precursor for several critical neurochemical reactions in the body. For example, L- trpotophan stimulates the release and production of serotonin and melatonin. Abnormalities in the production of serotonin and melatonin have been linked to behavioral and neurodevelopmental problems (Sandyk, 1992).

Researchers also measured the expression of genes known to be involved in metabolizing L-tryptophan. Patients with autism expressed some of these genes at lower levels as well.

Currently, ASD diagnosis depends upon a variety of assessments, including developmental evaluation and parental interviews. The average age of diagnosis is 4.5 years of age, yet symptoms may appear as early as 18 months. No diagnostic blood tests exist to accurately diagnose ASDs.

AutismBloodTest_m_0429

Researchers at GGC are hopeful that their finding may lead to the development of an earlier blood-screening test for autism. A blood test that identifies low levels of L-tryptophan may allow doctors to identify metabolic deficits in the brain. In other words, the test would examine the gene’s expression in attempt to distinguish between children with and without ASDs.

SynapDx, a laboratory services company, is funding the study in hopes of developing and marketing the blood test. SynapDx completed a study in 2012 using an in-house developed blood test as a means of autism diagnosis. The study blindly compared 170 children with ASDs and 115 without. The blood test correctly identified the children two-thirds of the time. This trial’s success has led the company to continue conducting further studies in hopes of validating the development.

The release of a screening test could validate doctors’ clinical evaluations and diagnosis of ASDs. While a blood test may not offer sufficient evidence to diagnose ASD independently, it will certainly decrease the amount of time of needed to confirm a diagnosis. Using a clinically significant blood test in conjunction with patient evaluations will increase the validity and objective nature of a diagnosis.

An earlier diagnosis will allow for more effective and timely therapies for affected children and families. Speeding up the diagnostic process will grant families access to treatments earlier, allowing for better results. The National Institute of Health has granted additional funding to GGC’s autism research in hopes of turning this recent finding into a simple blood test for autism.

In addition, this information helps researchers to better understand a possible biochemical mechanism behind ASDs. These findings provide evidence that the disorder may be related to the metabolic pathways involving L-tryptophan. This finding allows will researchers to further focus on the exact point that the disruption is occurring.

Important discoveries such as these bring research organizations one step closer to improved ASD diagnosis and therapy. To read more about this study, click here.

Because clinical and neurobiological research is constantly advancing, staying up to speed with groundbreaking research can be extremely overwhelming for families. However, The Autism Research Foundation (TARF) believes staying informed is key to promoting awareness and a better understanding of autism. TARF hopes to assist you in keeping up with the latest research by updating this blog on a regular basis, as well as hosting the Current Trends in Autism Research Conference.

Citations:

Boccuto, Luigi, Chin-Fu Chen, Ayla Pittman, Cindy Skinner, Heather McCartney, Kelly Jones, Barry Bochner, Roger Stevenson, and Charles Schwartz. “Decreased Tryptophan Metabolism in Patients with Autism Spectrum Disorders.” Molecular Autism 16 (2013): 4-16.

Greenwood Genetic Center. Advancement Paves Way for Early Blood Test and Therapeutic OptionsGreenwood Genetics – GGC Reports Autism Discovery. 5 June 2013. Web.

Sandyk, R. “L-tryptophan in Neuropsychiatric Disorders: A Review.” International Journal of Neuroscience (1992): 127-44.

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Fundraising That Helps Your Autism Programs, Too!

Beads for a Cause™ designs quality, cause-conscious jewelry that represent charities that are most meaningful to you. Beads like this “I See You” design symbolize a person’s commitment to autism awareness, research, education and inclusion, while a percentage of sales goes directly toward those efforts by The Autism Research Foundation. Use this bead to fundraise for your autism programming, too!

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theautismresearchfoundationFundraising That Helps Your Autism Programs, Too!
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Measles Surge in Britain after Autism Related Vaccine Scare

Last year, the United Kingdom had a record breaking 2,000 cases of measles. The U.K. has already reported more than 1,200 cases in 2013 thus far. The country now ranks second in Europe for the highest occurrence of this contagious disease, falling only behind Romania. This is a dangerous, life-threatening sickness that can easily be eliminated with proper preventative care. Researchers believe these numbers can be attributed to a decrease in the number of parents choosing to vaccine their children, representing a great medical setback.

Doctors believe unfounded fear of vaccines, spurred by Andrew Wakefield’s un-scientific 1998 publication, to be the cause of this measles outbreak in the United Kingdom. Wakefield’s highly flawed findings suggested a causal relationship between the childhood vaccine “MMR” and autism. The MMR vaccine is an immunization vaccine responsible for protection against Measles, Mumps, and Rubella. Parents of over one million children in Britain refused to vaccinate their child with the MMR vaccine in fear of increasing their child’s risk for autism.

Since that time, it is imperative to note that Wakefield’s findings have been rejected by numerous major medical groups and the paper was eventually retracted. The MMR vaccine — distributed to hundreds of millions of people globally — has a proven record of safety. The General Medican Council applied it’s most severe sanction to the case and banned Wakefield from continuing to practice medicine. Despite substantial objections to this outdated research, his work leaves behind a legacy of the “Wakefield scare.” And still, over a decade later, many parents remain fearful of the MMR vaccine’s potential effects.

MMR vaccine

Concerned health officials are trying to stop this epidemic by opening emergency vaccination clinics throughout Britain. The majority of diagnosed individuals are older children and teens who were never vaccinated. Officials hope to reach 1 million children aged 10 to 16 with these emergency clinics.

The first measles vaccine –introduced in the 1960′s — has drastically reduced the number of measles cases in children. By 2001, measles deaths dropped by 70 percent worldwide. However, the disease remains one of the leading causes of death in children under age 5, killing more than 150,000 people every year. This contagious disease is most common in developing countries. It is spread by coughing, sneezing, and close contact with infected people. Symptoms include fever, cough, and a rash on the face.

Britain’s Department of Health strongly advises parents to immunize their children. However, unlike many states in the United States, children in the U.K. are not required to receive proper vaccinations before beginning school. The measles vaccination rate in the U.S. remains above 90 percent, with only 55 reported cases last year.

The “Wakefield scare” may continue to have a detrimental effect on the health of children and teens in the U.K. until MMR rumors are abandoned. Fortunately, a trend away from the rumors seems to be occurring as currently 90 percent of children under 5 in the U.K. have received the necessary vaccines. However, vaccination is below 50 percent for children aged 10 to 16 in some regions. Hopefully the emergency vaccination clinics can address this gap and British health officials will continue to encourage the dismissal of any remaining MMR rumors.

So how can you help? Do your part to ensure your child’s health safety and stay informed on the latest research regarding important vaccinations! Share this post on your social media by using the buttons on the top and bottom of this page. And, of course, consult with your child’s physicians to learn of all the associated with the MMRE vaccine.

To learn more about this story, visit this site.

Citations:

Associated Press. “Measles Surge in Britain Years after Vaccine/autism Scare.” Fox News. FOX News Network, 20 May 2013. Web.

John Burns. “British Medical Council Bars Doctor Who Linked Vaccine with Autism.” The New York Times (2010). at <http://www.nytimes.com/2010/05/25/health/policy/25autism.html?_r=0>

Godlee F ,Smith J ,Marcovitch H. Wakefield’s article linking MMR vaccine and autism was fraudulent. BMJ 2011;342:c7452

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Poem: Fall in New England

Fall in New England

Fall is such a beautiful time of year

There are plenty of sites to see here

Leaves with bright colors orange, yellow, and red

Signaling a change that the year is near the end

But fall is also a time of new beginnings

It is a time to start to learn new things

A time to look at the world in a different way

A time to learn new strategies to handle each day

Let’s take this time of change

And focus on new ways to think

Let’s give individuals with challenges a new look and rearrange

And find a common link

Fall reminds us to turn over new leaves

To think about starting new goals to achieve

I call on the world to change perceptions

And give all of us a new reception

I want to make new friends and create a new start

I like to develop new relationships with an open heart

I hope to be accepted for the person that I am

So people can understand a true autistic man

— Scott Lentine, a smart, poetic and inspiring 26-year-old man who happens to have autism.

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Gaze Shifting Testing for Earlier ASD Diagnosis

As mentioned in a previous blog post, the U.S. Department of Health and Human Services now estimates roughly 1 in 50 school-aged children are diagnosed with Autism Spectrum Disorder (ASD).  This estimated increase in ASD prevalence suggests that steps are being taken to improve diagnosis of the disorder. ASD is not generally diagnosed until after three years of age, yet a recent study published in the American Journal Psychiatry examined the possibility of diagnosing ASD in children as young as seven months old.

This study included fifty-seven “high-risk” infants with an older sibling diagnosed with ASD and forty “low-risk” infants with typically developing older siblings. The infants participated in the study at seven months old and returned for a clinical assessment after their second birthday. This assessment determined which of these children should be diagnosed with ASD. Knowledge of their diagnosis was then used to analyze the study’s data.

The study measured the brain activity and amount of time required for a seven month old infant to shift their gaze during a visual attention task. Researchers compared the eye movements and visual attention of infants later diagnosed with ASDs, to those of a typically developing infant of the same age.

To do so, researchers engaged infants in the Gap/Overlap Task. During the Gap Task, infants sat on their parent’s laps and watched images appear on a monitor. The first image appeared in the center of the screen, attracted the infant’s gaze, and then disappeared. A gap of time passed before a second image appeared on the edge of the screen. Advanced eye tracking equipment captured the infant’s eye movements. These measurements provided researchers with the exact timing of the shift in gaze.

The Overlap Task measured eye-movements as well, but also included a measure of brain activity. During this portion, the image remained in the center of the screen, while a second image appeared at the edge. Eye tracking equipment measured the time it took infants to shift their gaze to the peripheral image. Using functional Magnetic Resonance Imaging (fMRI), the researchers also measured the amount of processing occurring in different regions, in the infant’s brain to determine if there were patterns that distinguished the two groups.

Results showed a difference of 25 to 50 milliseconds on average between infants later diagnosed with ASD and their typically developing counterparts.  Researchers believe this delay can be accounted for by differences in the developing neurological circuits of a child’s brain. During this period of early infancy, the brain’s pathways for communication are forming quickly. These pathways influence how the infant interprets and responds to the environment.

Researchers identified the splenium of the corpus callosum as one such pathway that may be related to the difference in gaze shifting. This structure is an important neural connection between the brain’s left and right hemisphere. Results revealed a correlation between large splenium size and the speed with which infants shift their gaze. The ability of an infant to rapidly switch gazes improved with increased size of the splenium in typically developing infants.

However, researchers found no similar correlation in infants later diagnosed with ASD.

Although 25 milliseconds seems brief, this delayed reaction time implies a possible overall difference in the way the infant’s brain is developing. A small delay at this early stage may hint at larger differences in cognitive and social development. Thus, this attention shifting delay may well serve as a precursor to other well-known symptoms of autism. Such symptoms including difficulty making eye contact and coordinating gaze. Research consistently suggests an association between autism and deficits in pursuit eye movement. Further gaze testing research may allow professionals the opportunity to predict the development of these symptoms as opposed for waiting for them to occur.

By detecting neurological differences through research on subtle delays at the infant stage of development, researchers hope to improve ASD diagnosis at an earlier age. Earlier diagnosis will help parents to recognize their infant’s needs and begin working to help their child reach his or her full potential. These potential diagnostic tools such as fMRI might be useful longitudinally as well to chart an individual’s progress during early intervention therapies.

To read more about this study, check out the full article.

Citations:

NIH/National Institute of Child Health and Human D. “Gaze Shifting Delay Has Potential To Diagnose Autism At 7 Months.” Medical News Today. MediLexicon, Intl., 27 Mar. 2013. Web. <http://www.medicalnewstoday.com/releases/258189.php>

Takarae, Y., Minshew, N., Luna, B., Krisky, C. & Sweeney, J. Pursuit Eye Movement Deficits in Autism. Brain: A Journal of Neurology 127, 2584–2594 (2004).

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10 Reasons to Donate

Hi Friends,
Our online community has asked our staff to provide ten (10) reasons for why people should donate to The Autism Research Foundation this holiday season. Is it cliche to say that the hardest part of this challenge was narrowing down our reasons to such a short list? Well, it was!
Here is our cheat sheet for why you should consider giving a gift to a charity that gives all year-round:
  1. The Autism Research Foundation is the first medically-accredited autism research charity in the world. Our longevity proves we have stood the test of time as a trusted authority in the field.
  2. Dr. Margaret Bauman spearheads our research. She is the recipient of the Lifetime Achievement Award of the International Society for Autism Research among an impressive 92-page curriculum vitae. It’s single-spaced! (And you can read it here.)
  3. We believe donations should pass through us, not to us. Whether you donate to research or a conference — or anything in between — your donation makes an immediate impact on the community we serve.
  4. Our charity operates entirely on volunteers. Between internships and returning helpers, our community donates their time and talent repeatedly each year — even as they move onto full-time careers elsewhere. That’s a testament to our mission and its why we can keep our overhead costs so low.
  5. We admit that we do not know it all, but we are so motivated to try! An autism diagnosis lasts a lifetime, and with it comes a lifetime of experiences that really do make the day-to-day tasks harder. We research to help you make better sense of the autism experience, and we aren’t too proud to say that there’s a long way to go, but you’ve got a friend in us and we are happy to help you along the way.
  6. Every staff member of The Autism Research Foundation is required to spend time in an autism clinic and an autism inclusion program: speaking with the people who live with autism everyday and building relationships with the parents/caregivers who help them navigate that different life. When you speak to a TARF staff member, you can be sure that they have a closer understanding of what you’re going through first-hand. 
  7. You can make donations in tribute to someone you value — check a gift (or ten!) off your list! We will send anyone — your best friend, child’s teacher, neighbor, therapist, or the President — a card letting him/her know you were thinking of them.
  8. We believe in a whole-person, whole-body understanding of autism: that you need to invest time in getting to know the person who happens to have autism first, before getting to know their autism characteristics.
  9. Every year, we host The Autism Research Consortium to encourage collaborative work across all healthcare and science disciplines. We share our information with an exclusive, small, and trusted network of professionals who are genuinely committed to helping families over raising illegitimate dollars from big corporate sponsors. Truthfully, we’d rather be poor and be able to sleep at night with a free conscience.
  10. Our doors are open to you. Anytime. We never turn families away from services for an inability to pay and we encourage supporters to walk-through our lab and learn what their donations, volunteer hours, and passion contribute to every day.

Follow The Autism Research Foundation on Facebook, Twitter, Instagram, and Pinterest to learn all of the ways our charity gives you reasons to give. Thank you for considering us!

Love,

Courtney and the TARF staff

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Poem: Can’t See You

Scott writes poetry and — through his poems — shares his experience of life on the spectrum. He is a great friend of our founding director, Dr. Margaret Bauman, and both of us are proud to share his poems with you.

Scott Lentine is a 25-year-old man with high-functioning autism (PDD-NOS/Asperger’s) from Billerica and summer resident of Fieldston Beach, Marshfield. Scott graduated from Merrimack College magna cum laude with a Bachelor’s Degree in Religious Studies with a Biology minor. Currently, Scott is an office intern at the Arc of Massachusetts in Waltham, where he tries to persuade lawmakers to pass key disability resources legislation to improve the lives of people with developmental disabilities.

Scott is interested in data clerical entry duties, hospital settings, autism non-profit organizations, and research type work. He even got a support letter email from President Obama for autism advocacy! Scott’s interests include poetry, politics, music, movies, science and medicine, various religions, traveling, going to Boston, dogs, and the beach.

Can’t You See

Can’t you see
I just want to have a friend
Can’t you see
I need the same connections in the end

Can’t you see
I want a good job
Can’t you see
I need to have stability and dependence and part of the general mob

Can’t you see
I want to be independent on my own
Can’t you see
I want to be able to have my own home

Can’t you see
I want the same things as everyone else
Can’t you see
I want to be appreciated for myself

~

Scott and his brother at a Boston Celtics game

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Batman Saved More Than Bedtime

When we moved our family almost 3000 miles away from their cousins, I knew the separation would be hard.

My girls and my sister’s boys have grown up together since birth. They love Lilly for who she is and have never seen her as any different than that. After a horrific trip home this past summer, I soon realized flying across country with my autistic angel just might not be in the cards for awhile.

How was I going to keep the connection going?

My angel loves watching pictures and videos of the boys, but never asks for them or does more than a whine and then kiss on the phone. I just had to keep the faith to talk to both my daughters equally about their boys in California, show pictures, tell stories. One of the difficult aspects of autism is not knowing what their minds are absorbing. I know my Lilly is extremely bright, but it’s never easy or normal to not receive answers to questions we try to ask her.

A couple weeks ago, I was blessed with a sneak peek inside her precious mind. Every day around noon the doorbell rings, and I prompt Lilly to go answer it. It is always one of her amazing therapists arriving for her in-home ABA therapy. On this day, she pranced through the hallway, long legs and tip-toes as always, but cried when she opened the door. To my complete and utter amazement, she whined, “No Miss __.” “Dane! Dane!”

There it was. More than a year from moving away, she asked for her adoring cousin. I immediately jumped on FaceTime with my sister so Lilly could see his face, but more importantly so my nephew knew she was here, asking for him. I ran into the kitchen, grabbed his proud soccer picture from the fridge and put it in her therapy room. My gut told me to keep the momentum going. I felt this strong urge to hold onto this seemingly unimaginable moment forever.

batmanmaskShe has not asked for him since, but found a Batman mask given to her by the boys on our trip home. Lilly had regressed on that trip — humming constantly, little to no language, wandering — and the only thing that seemed to calm her was the mask. It acted as a comfort, an escape: heartbreaking and adorable wrapped in the same breath.

Of course my generous and loving nephews let her keep it.

Lately, and, honestly, most of her life, Lilly’s bedtime routine has been a nightmare to say the least. So last night, when she insisted on bringing the hard plastic mask to bed, I didn’t flinch. Anything to calm her and not cause aggression and a meltdown, I figured.

As if she was recalling a memory, my sweet girl slid the mask on, smiled one of her room-lighting, angelic grins, and peacefully closed her eyes. My heart sang: confident that this one simple toy is serving as a link, a physical connection to recall her memory of time spent with her boys.

Most people wear a mask to keep the world out, but Lilly wears hers to let the world in. I bet Batman never knew he had the ability to save a little girl like this.

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